Mottled pigmentation with neuropathy, an enigma solved!

The staurolite enigma solved.

Staurolite has been long considered an enigma because of its remarkable pseudosymmetry and the frequent twinning. Staurolite gives two twins whose occurrence frequency seems to contradict the condition of lattice restoration requested by the reticular theory of twinning, in that the more frequent one (Saint Andrews cross twin) has a twin index of 12, whereas the less frequent one (Greek cross t...

[Electrocardiography and posterior wall infarction: has the enigma been solved?].

The cause of sarcoidosis: the Centurial enigma solved.

I am an experienced pathologist (4 decades), and I can now confidently perceive the cause of sarcoidosis. I can see clearly now because of 2 things: (1) modern evidence indicating a genetic-based immune dysregulation as an essential predisposing causal cofactor and (2) a century of accumulated pathology observations relevant to the point. The first factor helps explain numerous environmental, c...

Epidermolysis bullosa simplex with mottled pigmentation: a family report and review.

Epidermolysis bullosa simplex with mottled hyperpigmentation (EBS-MP) is an uncommon subtype of EBS. Its clinical features depend on the age of diagnosis, and clinical variations have been described even within family members. We present six cases from two unrelated Spanish families each with several affected members with EBS-MP and review the clinical and genetic findings in all reported patie...

Primary angiitis of the CNS--an enigma that needs world-wide efforts to be solved.

Primary or isolated angiitis of the central nervous system (PACNS) is still one of the enigmas in clinical neurology. Diagnostic criteria for the diagnosis of PACNS include the symptoms of a multifocal or diffuse CNS-disorder with remitting or progressive course, cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) findings supporting the diagnosis of vasculitis, and finally either an...